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Significant metabolic effects decline within 710 days, but some drug lingering may persist for 23 weeks depending on individual factors

However, 'average' masks critical individual variation: some semaglutide patients lose more weight than some tirzepatide users, proving that the 'better' medication depends on your physiology, not the drug class alone

Future Perspectives The central hypothesis emerging from current evidence is that oligodendroglial lipid reserves operate as a conditional metabolic buffer: they can be mobilized to sustain axonal ATP production when glycolytic supply falters, provided that redox burden, iron handling, and local pH remain within safe bounds

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